There is no ideal LA solution for all applications; however, we have found the buffered combination solution of lidocaine and bupivacaine with epinephrine to be extremely versatile in plastic surgery.
Buffered bupivacaine and lidocaine had a significantly longer anesthetic effect than that of the nonbuffered solutions (P < .05). No significant effect on corneal epithelial healing time or corneal toxicity was observed. Topical bupivacaine and lidocaine had a longer anesthetic effect, particularly in buffered solutions. No significant corneal Sep 25, 2019 · At 60 min, chondrocyte viability was significantly (P < 0.05) decreased when exposed to 0.5% levobupivacaine (32.5%), or 0.25% or 0.5% bupivacaine (34.3% or 46.5%, respectively) compared with exposure to phosphate-buffered saline (PBS) vehicle as a control. Cell death at 120 min was mainly necrosis. We conducted a prospective double-blind randomised trial to compare bupivacaine 0.5%; a 50 : 50 mixture of bupivacaine 0.5%/lignocaine 2% with 1 : 200 000 adrenaline (final concentration); and Bupivacaine (0.5%) or HEPES-buffered saline (containing, in mM: 140 NaCl, 3 KCl, 25 glucose, 1 CaCl 2, 1 MgCl 2, and 10 HEPES) at acidic pH (5.5, experimental) or alkalinized pH (7.2, control) was delivered locally to the L5 DRG in vivo by using procedures as described in detail below. To quantitatively assess the partitioning effect, the concentration of bupivacaine in the buffered solutions or serum was previously measured. 3, 23 Using gas chromatography, Mazoit et al. 3 showed that the concentration of bupivacaine was decreased from 430 to 140 μM by 1% lipid emulsion in the buffered solutions (pH 7.4).
Buffered Bupivacaine 1. Ackerman WE, Ware TR, Juneja M, The Air-Liquid Interface and the pH and PCO2 of Alkalinized Local Anaesthetic Solutions, Canadian Journal of Anaesthesia, Vol. 39, P. 387 (1992).
bupivacaine or less have fewer chondrotoxic effects on osteoarthritic cartilage. Studies show that chondrotoxicity increases with time after exposure and increases from ropivacaine to bupivacaine. Conclusion: Both ropivacaine and bupivacaine are chondrotoxic to human cartilage in a time-dependent, drug-dependent, and concentration-dependent manner. Buffered bupivacaine and lidocaine had a significantly longer anesthetic effect than that of the nonbuffered solutions (P < .05). No significant effect on corneal epithelial healing time or corneal toxicity was observed. Topical bupivacaine and lidocaine had a longer anesthetic effect, particularly in buffered solutions. No significant corneal Sep 25, 2019 · At 60 min, chondrocyte viability was significantly (P < 0.05) decreased when exposed to 0.5% levobupivacaine (32.5%), or 0.25% or 0.5% bupivacaine (34.3% or 46.5%, respectively) compared with exposure to phosphate-buffered saline (PBS) vehicle as a control. Cell death at 120 min was mainly necrosis.
After AAG and HSA, erythrocytes represent the third buffer system. In infancy, physiologic anemia diminishes the importance of the erythrocyte system. When total blood concentrations increased from 2 to 20 μg/ml, the proportion of bupivacaine molecules buffered by the erythrocytes increased from 15 to 22%.
Mar 08, 2011 · To address triamcinolone acetonide, bupivacaine, and combinatorial toxicity to human chondrocytes, we set up monolayer chondrocyte cultures (n = 8 wells per condition). The question of buffering was addressed by performing the same assays as above, but the reagents were buffered. After AAG and HSA, erythrocytes represent the third buffer system. In infancy, physiologic anemia diminishes the importance of the erythrocyte system. When total blood concentrations increased from 2 to 20 μg/ml, the proportion of bupivacaine molecules buffered by the erythrocytes increased from 15 to 22%.